Mechanistic Insights into a Four-Component Catellani Reaction: How Self-Inhibition Governs Electrophile Ordering
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B Xiao, C Yang, J Yin, TY Sun
Organic Chemistry Frontiers, 2026
pubs.rsc.org
Multicomponent coupling is a powerful strategy to rapidly build complex molecules, yet its broader application is often limited by poor chemoselectivity arising from competing cross-couplings among multiple substrates. Luan and co-workers recently disclosed a four-component Catellani reaction that enables sequence-controlled ortho difunctionalization of aryl iodides, in which benzoic anhydride and benzyl bromide undergo oxidative addition in a defined order. However, the mechanistic origin of this electrophile ordering has remained …
