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Studies on psychomotoric effects and pharmacokinetic interactions of the new calcium sensitizing drug levosimendan and ethanol复制

用户C1obCirZLenc 6小时前 16 10 求助中 帖子自动结束时间: 2026-11-18 16:39:25

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DOI:复制

文献链接: https://pubmed.ncbi.nlm.nih.gov/9272237复制

其他信息:

PMID: 9272237
作者: S Antila; A Järvinen; J Akkila; T Honkanen; M Karlsson; ...
摘要: Levosimendan (CAS 141505-33-1) is a calcium sensitizing drug intended for the treatment of congestive heart failure. In animal experiments levosimendan has potentiated the sedative effects of ethanol. Due to poor water solubility of the compound, ethanol is used as a diluent in the intravenous formulation. In this study the possible interactions between levosimendan and ethanol in human have been studied. Twelve healthy male volunteers were included in this double-blind, randomized, cross-over s...

上一篇：Integrated pharmacokinetics and pharmacodynamics of the novel calcium sensitizer levosimendan as assessed by systolic time intervals

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