Novel Therapies for Generalized Myasthenia Gravis: Insights Into FcRn and Complement Inhibition
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VC Samara, N Thottempudi, O Franke…
American Journal of …, 2026
journals.lww.com
Background: Myasthenia gravis (MG) is a rare autoimmune neuromuscular disorder with significant unmet needs despite conventional therapies. Novel FcRn and complement inhibitors have transformed the treatment paradigm for generalized MG. Methods: This commentary reviews the clinical efficacy, safety, and practical implications of FDA-approved FcRn inhibitors (efgartigimod, rozanolixizumab, nipocalimab) and complements inhibitors (eculizumab, ravulizumab, zilucoplan), drawing on clinical trial data and literature from 2013 …
