FcRn inhibitors: A new era in neurotherapeutics
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JF Howard, JT Guptill
Handbook of Clinical Neurology, 2026
Elsevier
Abstract The neonatal Fc receptor (FcRn) is a heterodimeric protein that binds albumin and immunoglobulin G (IgG) to mediate pH-dependent recycling, prevent degradation, and maintain their serum concentrations. The ability to bind IgG means FcRn plays both beneficial and potentially detrimental roles in host immunity. Beneficially, FcRn maintains first-line defenses against invading pathogens by preventing degradation of IgG in mucosal secretions, and is linked with increased tumor protection via IgG immune complex–mediated …
