Examining hybridization-based LC–MS methodologies for the bioanalysis of siRNA analytes
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K Agrawal, W Jian, L Yuan
Bioanalysis, 2025
Taylor & Francis
Hybridization-based LC–MS is rapidly emerging as a bioanalytical platform for oligonucleotides, particularly when both high sensitivity and high specificity are needed. When used to analyze single-stranded antisense oligonucleotide (ASO) therapeutics, the workflows are relatively well established, but the analysis of double-stranded small interfering RNA (siRNA) therapeutics presents additional challenges due to competition for binding from the sense strand. In the last two years, the authors have independently …
