Functional Analysis of the Coronary Artery associated gene SVEP1
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S Andrews
2021
figshare.le.ac.uk
Background: A low frequency missense variant in Sushi, von Willebrand factor type A, EGF and pentraxin domain containing protein1 (SVEP1) is associated with coronary artery disease (CAD) but the contributory mechanisms are currently unknown. We investigated the role of SVEP1 in CAD relevant disease processes. Methods and Results: Expression profiling revealed an up-regulation of SVEP1 during monocyte to macrophage differentiation, leading us to investigate the role of SVEP1 in inflammatory processes …
