Synthesis of trans N-Substituted Pyrrolidine Derivatives Bearing 1,2,4- triazole Ring
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TN Prasad, YP Reddy, PC Settipalli…
Current Organic …, 2022
benthamdirect.com
Background: 1, 2, 4-triazoles scaffolds display significant biological activities due to hydrogen bonding, solubility, dipole character, and rigidity. Objective: The core motif of 1, 2, 4-triazoles plays a vital role in clinical drugs such as Rizatriptan (antimigraine), Ribavirin (antiviral), anastrozole (anticancer), etizolam (anxiolytic), estazolam (anticonvulsant), alprazolam (anti-hypnotic), letrozole (aromatase inhibitor), loreclezole (anticonvulsant), trazadone (antidepressant) etc. Methods: Epoxide ring opening of tert-butyl 6-oxa-3 …
