Synthesis, Reactions, and Biological Applications of 1, 2, 4-triazoles: A Review
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AA Aly, AA Hassan, NK Mohamed…
Current Organic …, 2025
benthamdirect.com
Compounds containing the 1, 2, 4-triazole substructure have been shown to have broad biological activities. Many drugs with a 1, 2, 4-triazole structure have been developed and proven: for example, ribavirin (antiviral), fluconazole, itraconazole, voriconazole (antifungal), alprazolam (tranquilizer), estazolam (hypnotic, sedative), anastrozole, vorozole and letrozole (as non-steroidal aromatase inhibitors). Given the importance of 1, 2, 4-triazole scaffolds, the synthesis of their derivatives has attracted much attention. This review deals …