Buffer compositions strongly impact the in vitro assessment of CYP fraction metabolized using human liver microsomes or expressed isoenzymes
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DOI: 10.1016
文献链接: https://doi.org/10.1016/j.dmpk.2025.101480
其他信息:
Buffer compositions strongly impact the in vitro assessment of CYP fraction metabolized using human liver microsomes or expressed isoenzymes
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Yuta Tamemoto a b
,
Yukihiro Shibata a c
,
Natsumi Hashimoto a
,
Aoi Yoshitomo a
,
Shizuka Hozuki a
,
Keita Takahashi a
,
Hana Kumemura a
,
Hiroto Hatakeyama a b
,
Hiromi Sato a
,
Akihiro Hisaka a
a
Laboratory of Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8675, Japan
b
Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8675, Japan
c
Faculty of Pharmacy at Narita, International University of Health and Welfare, 4-3, Kozunomori, Narita-shi, Chiba, 286-8686, Japan
Received 22 January 2025, Revised 21 February 2025, Accepted 13 March 2025, Available online 14 March 2025, Version of Record 9 May 2025.
