Microbiome-produced nicotinic acid controls colon regional identity and injury susceptibility
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DOI:
文献链接: https://www.cell.com/cell/abstract/S0092-8674(26)00172-8
其他信息:
J Rispal, JR Garcia, B Palikuqi, M Vegesna, D Vaka…
Cell, 2026
cell.com
The regionalized structure of the intestinal epithelium is critical for its function, and the risk for certain diseases has a regional bias. However, how regionalization is established and how it influences disease susceptibility remain poorly understood. Here, we investigated the role of the gut microbiome—the regionalized community of microorganisms in the intestinal lumen—in promoting regionalization of the colon. We found that the proximo-distal identity of colonocytes along the organ
