Effects of SP500263, a novel, potent antiestrogen, on breast cancer cells and in xenograft models
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/11888917
其他信息:
PMID: 11888917
作者: Helen Brady; Sonal Desai; Leah M Gayo-Fung; Sak Khammungkhune; Jeffrey A McKie; ...
摘要: We have compared the antitumor activities of SP500263, a novel next-generation selective estrogen receptor modulator (SERM), tamoxifen, and raloxifene side-by-side in in vitro and in vivo MCF-7 breast cancer models. In vitro, SP500263 acted as an antiestrogen and potently inhibited estrogen-dependent MCF-7 proliferation with IC(50) values in the nanomolar range. SP500263 also strongly inhibited MCF-7 proliferation in the absence of estrogen at all of the concentrations tested. To investigate the...
