[Antitumor activity of a new antiestrogenic drug, toremifene (NK622) against human breast cancer xenografts in nude mice]
DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/8470919
其他信息:
PMID: 8470919
作者: S Kuroiwa; M Koyama; N Watanabe; H Ekimoto; Y Ohnishi; ...
摘要: NK622, a novel tamoxifen(TAM) analog with nonsteroidal structure is an antiestrogenic drug with less toxicity compared with that of TAM. We studied the in vivo antitumor activity against human breast cancer xenografts in nude mice. NK 622 significantly inhibited the growth of estrogen-dependent Br-10 breast cancer but not inhibited the growth of estrogen-independent MC-2-JCK and MC-5-JCK when orally administered once daily for 14 days at the maximum tolerated dose (200mg/kg/day). The dose of NK6...
