Mutant-selective T-cell receptor therapy for solid tumors
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S Parry, CQ Jang, A Leal…
Molecular Cancer …, 2026
aacrjournals.org
Advanced solid tumors remain largely incurable, with most patients ultimately progressing despite modern therapies, including immune checkpoint blockade. The limited impact of these approaches reflects the biological complexity of solid tumors, including intratumoral heterogeneity, an immunosuppressive microenvironment, and the predominance of “undruggable” oncogenic drivers. Adoptive cellular therapy (ACT) offers a complementary strategy by delivering tumor-specific lymphocytes directly into patients. Among ACT …
