期刊论文Mercuric chloride-treated brown Norway rats develop widespread tissue injury including necrotizing vasculitis.复制

DOI:复制

文献链接:复制

其他信息:

PW Mathieson, S Thiru, DB Oliveira
Laboratory Investigation; a …, 1992
europepmc.org
Background Mercuric chloride (HgCl2) induces a T cell-dependent autoimmune syndrome in Brown Norway (BN) rats, characterized by polyclonal B cell activation and circulating autoreactive T cells. A number of autoantibodies are produced, including antibodies to glomerular basement membrane, and there are circulating immune complexes. However, histologic evidence of tissue injury in this model has previously been reported to be rare.