New approach to nonracemic 1-alkylamino-3-aryloxypropan-2-ols belonging to β-blockers via cyclic sulfites
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ZA Bredikhina, AV Pashagin, DV Savel" ev…
Russian Chemical …, 2001
Springer
Abstract Nonracemic β-blockers, viz.,(S)-propranolol and (S)-timolol, were prepared from (S)-glycidol in three steps consisting in the reaction with SOCl2 followed by the reaction of the resulting (4 S)-4-chloromethyl-2-oxo-1, 3, 2-dioxathiolanes with the corresponding phenol and the final cleavage of (4 R)-aryloxymethyl sulfites under the action of amines in DMF.
