New approach to nonracemic 1-alkylamino-3-aryloxypropan-2-ols belonging to β-blockers via cyclic sulfites
wiser36
6天前
31
10
已完结
1. 当前求助状态已完结, 请及时下载应助文件
2. 系统将在 2025-12-02 14:39:02 删除文件
注: 所有应助的资源仅供学习交流使用, 不得违反相关法律法规
DOI:
文献链接:
其他信息:
ZA Bredikhina, AV Pashagin, DV Savel" ev…
Russian Chemical …, 2001
Springer
Abstract Nonracemic β-blockers, viz.,(S)-propranolol and (S)-timolol, were prepared from (S)-glycidol in three steps consisting in the reaction with SOCl2 followed by the reaction of the resulting (4 S)-4-chloromethyl-2-oxo-1, 3, 2-dioxathiolanes with the corresponding phenol and the final cleavage of (4 R)-aryloxymethyl sulfites under the action of amines in DMF.
