A mechanistic biopsy study of the effect of iptacopan on immunopathology in patients with IgA nephropathy (IgAN)
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D Rizk, B Maes, H Zhang…
Nephrology …, 2025
medcommshydhosting.com
• Overactivation of the alternative pathway is one of the key drivers of IgAN. Targeting the alternative pathway may address an unmet need for targeted immunomodulation and result in the improvement of kidney function and prevention of disease progression1, 2• Iptacopan is a proximal complement inhibitor that targets factor B to specifically inhibit the alternative complement pathway while leaving signaling from the lectin and classical pathways intact1, 3, 4
