Effect of iptacopan discontinuation on proteinuria and complement biomarkers in patients with immunoglobulin A nephropathy (IgAN): a post hoc analysis from …
1. 文件大小不能超过300M, 允许上传文档或压缩包等
2. 请确保上传文献的真实性、完整性，不得对原文做任何修改
注: 所有应助的资源仅供学习交流使用, 不得违反相关法律法规
DOI:
文献链接:
其他信息:
J Barratt, D Rizk, H Zhang, B Maes…
62nd European …, 2025
medcommshydhosting.com
… • Treatment with iptacopan resulted in an early and meaningful reduction in proteinuria, and was associated with a strong inhibition of biomarkers of AP activation and sC5b-9 formation, as previously demonstrated • These post hoc data indicate that iptacopan discontinuation leads to reactivation of systemic and renal complement to near baseline levels • Proteinuria increased following iptacopan discontinuation and decreased again after reinitiation in the OLE, indicating that patients had continued sensitivity to complement …
