Effect of iptacopan discontinuation on proteinuria and complement biomarkers in patients with immunoglobulin A nephropathy (IgAN): a post hoc analysis from …
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J Barratt, D Rizk, H Zhang, B Maes…
62nd European …, 2025
medcommshydhosting.com
… • Treatment with iptacopan resulted in an early and meaningful reduction in proteinuria, and was associated with a strong inhibition of biomarkers of AP activation and sC5b-9 formation, as previously demonstrated • These post hoc data indicate that iptacopan discontinuation leads to reactivation of systemic and renal complement to near baseline levels • Proteinuria increased following iptacopan discontinuation and decreased again after reinitiation in the OLE, indicating that patients had continued sensitivity to complement …
