Suzetrigine for moderate to severe acute pain
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EB Cho, C Jiang, Z Wang, Y Yu, J Jiang
Trends in Pharmacological …, 2025
cell.com
STRUCTURE: Suzetrigine (VX-548), 2-pyridinecarboxamide, 4-[[[(2R, 3S, 4S, 5R)-3-(3, 4-difluoro-2-methoxyphenyl) tetrahydro-4, 5-dimethyl-5-(trifluoromethyl)-2-furanyl] carbonyl] amino]-, or 4-[[(2R, 3S, 4S, 5R)-3-(3, 4-difluoro-2-methoxyphenyl)-4, 5-dimethyl-5-(trifluoromethyl) oxolane-2-carbonyl] amino] pyridine-2-carboxamide, is a selective voltage-gated sodium channel 1.8 (NaV1. 8) blocker. It has a molecular formula C21H20F5N3O4 and a molecular weight of 473.4 g/mol. The molecule has a chiral tetrahydrofuran core (2R …
