Novel anti-HER2 nanobody-drug conjugates with enhanced penetration of solid tumor and BBB, reduced systemic exposure and superior antitumor efficacy
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Y Wang, L Liu, Q Yang, K Yu
Acta Pharmacologica Sinica, 2025
nature.com
… of HER2-ADC, we are … VHH-Fc fusions also demonstrated potent binding to HER2-ECD
via ELISA with EC 50 values ranging from 0.005–0.010 μg/mL (Fig. 1d). Similarly, the VHH-Fc …
