siRMSD: A Structural Parameter to Reduce Sequence-Dependent Off-Target Effects for siRNA Design with Chemical Modifications
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S An, K Ui-Tei
RNA Therapeutics: From siRNA to mRNA Innovations, 2025
Springer
RNA interference (RNAi) is a mechanism for regulating gene expression through small interfering RNAs (siRNAs), double-stranded RNA molecules approximately 20–23 nucleotides in length. The RNAi holds significant therapeutic potential for suppressing disease-related genes in a sequence-specific manner. Most commercially available siRNAs are extensively chemically modified to enhance stability or reduce immunogenicity. These chemical modifications also play a crucial role in mitigating off-target effects, which primarily …
