Receptor-effector coupling by G proteins
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L Birnbaumer, J Abramowitz, AM Brown
Biochimica et Biophysica Acta …, 1990
Elsevier
The primary structure of G proteins as deduced from purified proteins and cloned subunits is presented. When known, their functions are discussed, as are recent data on direct regulation of ionic channels by G proteins. Experiments on expression of α subunits, either in bacteria or by in vitro translation of mRNA synthesized from cDNA are presented as tools for definitive assignment of function to a given G protein. The dynamics of G protein-mediated signal transduction are discussed. Key points include the existence of two …