Total Synthesis of N-hydroxy Cyclic Peptide: Talarolide A
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WM Hussein, Y Zhu, AA Salim, RJ Capon
Peptide Synthesis: Methods …, 2025
Springer
This chapter reports the successful synthesis of talarolide A (1), a natural product exhibiting a unique hydroxamate H-bond bridge, through a carefully designed solid-phase approach. By systematically selecting the disconnection site, we synthesized a protected linear precursor, which was then sequentially deprotected and cyclized. We discovered that the order of deprotection and cyclization was critical: precyclization of the unprotected peptide facilitated the correct conformational folding essential for achieving the natural product's …
