THE SELECTIVE P2X3R ANTAGONIST DT-0111 DOES NOT AFFECT TASTE IN MICE. Medical Research Archives,[online] 13 (5)
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A Pelleg
2025
esmed.org
ABSTRACT Adenosine 5′-triphosphate (ATP) is found in every cell of the human body where it plays a critical role in cellular energetics and metabolism. ATP is released from cells under physiological and pathophysiological conditions. Extracellular ATP acts as an autocrine and paracrine molecule, the effects of which are mediated by cell surface purinergic receptors (P2R). The activation of P2X3R and P2X2/3R localized on vagal sensory nerve terminals has been implicated in the sensation of pain as well as multiple …
