ATP release and metabolism by human and guinea pig airways and P2X receptor‐dependent effects on bronchopulmonary vagal afferent nerve subtypes
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BJ Canning, M Yoshihara, N Mori…
British Journal of …, 2026
Wiley Online Library
Background and Purpose ATP‐dependent activation of P2X receptors has been implicated in chronic cough. The mechanisms of ATP release in cough and how P2X‐receptor engagement produces cough hypersensitivity are not clear. It is also unclear whether P2X receptor blockade could compromise the essential defensive functions of cough regulated by the vagal Aδ‐fibres terminating in the extrapulmonary airways. Experimental Approach We measured ATP release from isolated human and guinea pig airways. P2X receptor …
