Construction of axial chirality via palladium/chiral norbornene cooperative catalysis
1. 系统已在2025-11-18 16:11:23对应助文件进行删除
2. 如有需要请重新发布求助信息
注: 所有应助的资源仅供学习交流使用, 不得违反相关法律法规
DOI: 10.1038/s41929-020-0494-1
文献链接: https://www.nature.com/articles/s41929-020-0494-1
其他信息:
Construction of axial chirality via palladium/chiral norbornene cooperative catalysis
Nature Catalysis ( IF 44.6 ) Pub Date : 2020-08-10 , DOI: 10.1038/s41929-020-0494-1
Ze-Shui Liu , Yu Hua , Qianwen Gao , Yuanyuan Ma , Hua Tang , Yong Shang , Hong-Gang Cheng , Qianghui Zhou
Axially chiral biaryls are common structural motifs in functional materials, bioactive natural products, pharmaceuticals and chiral catalysts/ligands. As such, efficient preparation of these privileged scaffolds is an important endeavour in organic chemistry. Herein we report a general and modular platform technology for the construction of axial chirality via palladium/chiral norbornene cooperative catalysis. It is a three-component cascade process that involves widely available aryl iodides, 2,6-substituted aryl bromides and olefins (or alkynes, boronic acids and so on) as the reactants. A wide variety of substrates bearing an assortment of functional groups (88 examples) are compatible with this method.
