Iron-Catalyzed Oxidative Cross-Coupling of Phenols and Tyrosine Derivatives with 3‑Alkyloxindoles
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T Mintz, NY More, E Gaster…
The Journal of Organic …, 2021
ACS Publications
In this study, a novel iron-catalyzed oxidative cross-coupling reaction between phenols and 3-alkyloxindole derivatives is reported. The efficient method, which is based on the FeCl 3 catalyst and the t-BuOOt-Bu oxidant in 1, 2-dichloroethane at 70 C, affords 3-alkyl-3-(hydroxyaryl) oxindole compounds with a high degree of selectivity. The generality of the conditions was proven by reacting various substituted phenols, naphthols, and tyrosine derivatives with 3-alkyloxindoles. To apply the chemistry for the conjugation of tyrosine …
