Structural basis of disease mutation and substrate recognition by the human SLC2A9 transporter
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NK Khandelwal, M Gupta, P Kumar…
Proceedings of the …, 2025
pnas.org
Urate provides~ 50% of the reducing potential in human and primate plasma which is key to detoxifying reactive oxygen by-products of cellular metabolism. Urate is the endpoint of purine metabolism in primates, and its concentration in plasma is a balance between excretion from kidney and intestine, and subsequent reabsorption in and through cells of kidney proximal tubules to maintain a regulated concentration in plasma. SLC2A9 is the primary transporter that returns urate from the basolateral side of kidney tubule cells back to …
