Renal effects of uricosuric agents in the cebus monkey
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DOI: 10.1016/s0022-3565(25)28691-8
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GM Fanelli, DL Bohn, SS Reilly
The Journal of …, 1970
jpet.aspetjournals.org
The effects of known uricosuric agents have been examined by standard clearance techniques in male Cebus monkeys. Probenecid was effective in promoting uricosuria at po doses greater than 10 mg/kg. Sulfinpyrasone was only mildly active in this species. Zoxazolamine, at po doses sufficient to produce marked uricosuria in man, was inactive. Phenylbutasone was weakly active; carinamide did not elicit a uricosuric response under our experimental conditions. Iodopyracet at high loads was markedly uricosuric …