Breaking the Itch–Scratch Cycle: An Integrative Approach for Atopic Dermatitis
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M Steinhoff, G Yosipovitch, L Canchy…
Dermatitis®, 2025
liebertpub.com
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a significant psychological impact. The cardinal symptom of all phenotypes and severities is chronic pruritus with repetitive itching and scratching due to a vicious itch–scratch cycle that can be worsened or triggered by stress. Neuroimaging of brain areas responsible for itch processing in healthy subjects versus patients with AD has provided insights into the brain circuits involved in itch central perception. In patients with AD, the dorsolateral prefrontal cortex appears to be …
