Zilebesiran: A novel RNA interference therapeutic for hypertension
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D Maheta, F Shah, V Biba, NN Ngardig…
Cardiology in …, 2025
journals.lww.com
Hypertension remains a leading modifiable risk factor for cardiovascular morbidity and mortality, yet blood pressure control rates are suboptimal, partly due to adherence challenges with daily medications. Zilebesiran is an investigational small interfering RNA therapy targeting hepatic angiotensinogen synthesis to achieve prolonged suppression of the renin–angiotensin–aldosterone system. By conjugating the small interfering RNA to N-acetylgalactosamine, zilebesiran is delivered specifically to hepatocytes, leading to> 90 …
