Add-on treatment with zilebesiran for inadequately controlled hypertension: the KARDIA-2 randomized clinical trial
1. 文件大小不能超过300M, 允许上传文档或压缩包等
2. 请确保上传文献的真实性、完整性，不得对原文做任何修改
注: 所有应助的资源仅供学习交流使用, 不得违反相关法律法规
DOI:
文献链接:
其他信息:
AS Desai, AD Karns, J Badariene, A Aswad, JM Neutel…
JAMA, 2025
jamanetwork.com
Importance In prior monotherapy studies of patients with hypertension, single subcutaneous doses of zilebesiran, an investigational RNA interference therapeutic, reduced serum angiotensinogen levels and systolic blood pressure (SBP) at 3 and 6 months. Objective To evaluate the efficacy and safety of zilebesiran vs placebo when added to a standard antihypertensive medication. Design, Setting, and Participants This phase 2, randomized, prospective, double-blinded trial enrolled adults with uncontrolled hypertension from 150 …
