Stress degradation behavior of pregabalin, identification of degradation impurities and development of stability indicating UPLC method
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P Vukkum, JM Babu, R Muralikrishna
Stress, 2026
kgpublication.com
UPLC) method has been developed for the quantification of Pregabalin and its related impurities in drug substance. The stability-indicating capability of the developed method is demonstrated using forced degradation samples from stress conditions such as hydrolysis, oxidation, thermal and photolytic degradation. The separation of known impurities and degradation impurities are accomplished using a phenyl-hexyl stationary phase with 100 mm length and 1.7 µm particle size in short run time (10 min). The developed method …
