Effects of glycosaminoglycan polysulfate on extracellular matrix metabolism in human skin cells
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/8202631
其他信息:
PMID: 8202631
作者: S Mitsuyama; S Tanaka; F Urushizaki; T Yoshida; A Ito; ...
摘要: The effects of chondroitin polysulfate (CPS), a semi-synthetic oversulfated chondroitin sulfate, on the metabolism of extracellular matrix in human skin cells were examined. CPS accelerated the production of glycosaminoglycans (GAGs) in human dermal fibroblasts in a dose dependent manner (0.1-3.0 micrograms/ml), but did not modulate the production of noncollagenous protein and collagen, or [3H]-thymidine incorporation into DNA. However, higher concentrations (> 10 micrograms/ml) of CPS suppresse...
