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Product-specific impact of viscosity modulating formulation excipients during ultra-high concentration biotherapeutics drug product development复制

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D Rodrigues, LM Tanenbaum…
Journal of …, 2021
Elsevier
Developing ultra-high concentration biotherapeutics drug products can be challenging due to increased viscosity, processing, and stability issues. Excipients used to alleviate these concerns are traditionally evaluated at lower protein concentrations. This study investigates whether classically known modulators of stability and viscosity at low (

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