期刊论文One-month parenteral toxicity study of recombinant human basic fibroblast growth factor in dogs复制

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文献链接: https://pubmed.ncbi.nlm.nih.gov/10928692复制

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PMID: 10928692
作者: M Y Kim; M K Shin; J W Son; H I Kwak; M Z Fang; ...
摘要: A 1-mo toxicity study followed by a 1-mo recovery period of recombinant human basic fibroblast growth factor (bFGF) was performed using Beagle dogs at doses of 30, 120 or 480 mg/kg/d to estimate the no observed adverse effect level (NOAEL). Subcutaneous thickening was seen and its incidence, as well as that of stiffness of the injection sites, increased with dose. There were neither dead animals nor significant changes of body weight during the experimental period. In addition, no significant bF...