Bioanalytical methods for therapeutic monoclonal antibodies and antibody–drug conjugates: A review of recent advances and future perspectives
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K Todoroki, H Mizuno, E Sugiyama…
Journal of Pharmaceutical …, 2020
Elsevier
As the use and development of therapeutic monoclonal antibodies (mAbs) and antibody–drug conjugates (ADCs) increases, the need for accurate and robust bioanalytical methods is also increasing. Up to about a decade ago, bioanalysis of therapeutic mAbs was performed only by ligand-binding assay (LBA), and this was the only available method for absolute quantitation. Recent technological advances in liquid chromatography (LC)–tandem mass spectrometry (LC–MS/MS) and LC–high-resolution mass spectrometry can …
