Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/7909557
其他信息:
PMID: 7909557
作者: H E Shannon; F P Bymaster; D O Calligaro; B Greenwood; C H Mitch; ...
摘要: Xanomeline [3(3-hexyloxy-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1- methylpyridine] has been evaluated as a muscarinic receptor agonist. In vitro, xanomeline had high affinity for muscarinic receptors in brain homogenates, but had substantially less or no affinity for a number of other neurotransmitter receptors and uptake sites. In cells stably expressing genetic m1 receptors, xanomeline increased phospholipid hydrolysis in CHO, BHK and A9 L cells to 100, 72 and 55% of the nonselective agonis...
