Synthesis and characterization of impurities of an anticonvulsant drug, Pregabalin
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S Sripathi, NR Somesetti, R Veeramalla, NR Challa…
Arkivoc, 2010
researchgate.net
During the process development of Pregabalin 1, a known anticonvulsant drug, six potential impurities were identified in the final crude material ranging from 0.01 to 0.15% by LCMS. All six impurities were subsequently synthesized and characterized by IR, MS and NMR spectral data. Four of the six related substances are known as 4-isobutylpyrrolidin-2-one 6, 3-isobutylglutaric acid 2,(R)-(-)-3-carbamoylmethyl-5-methylhexanoic acid 5 and (R)-(-)-3-aminomethyl-5-methylhexanoic acid 8, whilst (S)-3-aminomethyl-5-methylhexanoic acid …
