A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma
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DOI:
文献链接: https://academic.oup.com/neuro-oncology/article-abstract/5/2/79/1070081
其他信息:
M Westphal, DC Hilt, E Bortey, P Delavault…
Neuro …, 2003
academic.oup.com
A previous placebo-controlled trial has shown that biodegradable 1, 3-bis (2-chloroethyl)-1-nitrosourea (BCNU) wafers (Gliadel wafers) prolong survival in patients with recurrent glioblastoma multiforme. A previously completed phase 3 trial, also placebo controlled, in 32 patients with newly diagnosed malignant glioma also demonstrated a survival benefit in those patients treated with BCNU wafers. Because of the small number of patients in that trial, a larger phase 3 trial was performed to confirm these results. Two hundred forty patients …
