Etiprednol dicloacetate, a new soft glucocorticoid drug candidate. Development of chemistry
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/15212300
其他信息:
PMID: 15212300
作者: A Csanádi; Gy Horváth; T Szekeres; T Haskó; L Ila; ...
摘要: During development of chemistry of the soft drug candidate etiprednol dicloacetate (BNP-166) 1) optimization studies on the three-step chemical synthesis resulted in a process that could be scaled-up to the kg level, 2) the impurity profile was determined, 3) synthetic routes were developed for the preparation of the radiolabeled target compound, and 4) a series of hydroxylated metabolites was prepared.
