Seven pillars of small airways disease in asthma and COPD: supporting opportunities for novel therapies
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OS Usmani, MLK Han, DA Kaminsky, J Hogg…
Chest, 2021
Elsevier
Identification of pathologic changes in early and mild obstructive lung disease has shown the importance of the small airways and their contribution to symptoms. Indeed, significant small airways dysfunction has been found prior to any overt airway obstruction being detectable by conventional spirometry techniques. However, most therapies for the treatment of obstructive lung disease target the physiological changes and associated symptoms that result from chronic lung disease, rather than directly targeting the specific …
