Nuclear receptor co-factor TBL1X/TBL1XR1 T cell activity protects against atherosclerosis
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SC Koker, A Mhamane, J Geppert, G Shakir…
Molecular …, 2026
Elsevier
Atherosclerosis is a long-term complication of obesity and diabetes and as such a key driver of vascular dysfunction and eventually mortality in affected patients. Both aberrant lipid metabolism and inflammatory reactions promote atherosclerotic plaque development in the vessel wall by triggering a cascade of cellular events involving multiple cell types, including smooth muscle cells, monocytic macrophages, and lymphocytes. Despite its eminent impact on human health, molecular drivers of cellular dysfunction in atherosclerosis remain poorly …
