Determination of clarithromycin in human plasma by liquid chromatography-tandem mass spectrometry: Validation and application in clinical pharmacokinetic study
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Z Xiang-rong, C Xiao-yan, LI Xiao-yan…
Journal of Chinese …, 2004
jcps.bjmu.edu.cn
Aim To develop a liquid chromatographic-tandem mass spectrometric (LC-MS-MS) method to determine clarithromycin in human plasma. Methods The analyte and internal standard roxithromycin were extracted from plasma samples by n-nexane-dichloromethane-isopropanol (300: 150: 15, V/V/V) and chromatographed on a C 18 column. The mobile phase consisted of methanol-water-formic acid (80: 20: 1, V/V/V). Detection was performed on a triple quadrupole tandem mass spectrometer via electrospray ionization source (ESI) in …
