期刊论文Nicotinamide N‐methyltransferase ameliorates renal fibrosis by its metabolite 1‐methylnicotinamide inhibiting the TGF‐β1/Smad3 pathway复制

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W Zhang, G Rong, J Gu, C Fan, T Guo…
The FASEB …, 2022
Wiley Online Library
Chronic kidney disease (CKD), a disease involving damage to the kidney structure and function, is a global public health problem. Tubulointerstitial fibrosis (TIF) is both an inevitable pathological change in individuals with CKD and a driving force in the progression of renal fibrosis. Nicotinamide N‐methyltransferase (NNMT) and its metabolite 1‐methylnicotinamide (MNAM) have been shown to protect against lipotoxicity‐induced kidney tubular injury. However, the biological roles of NNMT and MNAM in regulating TIF remain …