Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson's disease models
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S Du, Q Long, Y Zhou, J Fu, H Wu, L Yang, Y Xie…
Cell, 2026
cell.com
Mitochondrial transplantation holds significant potential for the treatment of mitochondrial diseases. However, how to efficiently deliver exogenous mitochondria to somatic cells or tissues remains unresolved. We present a mitochondrial transplantation approach to deliver mitochondria into the cells and tissues of mice and monkeys with high efficiency, based on encapsulating mitochondria with vesicles derived from the plasma membrane of erythrocytes. Treatment with encapsulated mitochondria complemented the loss, deletion, or …
