Bioequivalence of oral and injectable levoleucovorin and leucovorin
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/8458180
其他信息:
PMID: 8458180
作者: J M DeVito; G D Kozloski; A P Tonelli; J B Johnson; J M DeVito; ...
摘要: The bioequivalence and bioavailability of oral and intravenous formulations of levoleucovorin and leucovorin were studied, and the absolute bioavailabilities of levoleucovorin and leucovorin tablet formulations were determined. Healthy male volunteers participated in two randomized, single-dose, four-way crossover studies. The treatment groups were as follows: A = five 2.5-mg levoleucovorin tablets, B = five 5-mg leucovorin tablets, C = one 12.5-mg levoleucovorin tablet, D = one 25-mg leucovorin...
