Clinical Implications of Slope of GFR in Clinical Trials of CKD Progression
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CKD-EPI Clinical Trials …
… Journal of the …, 2025
utsouthwestern.elsevierpure.com
BackgroundSlope of the GFR is considered a validated surrogate endpoint for CKD trials. However, differing short-term and long-term treatment effects on GFR slope can create ambiguities concerning the appropriate period for evaluating slope, in part because current methods cannot separate the distinct contributions of the acute (before 3 months) and chronic (after 3 months) slopes for treatment effects on clinical endpoints (CEs). MethodsWe estimated treatment effects on the acute and chronic GFR slopes and on the established CE …
