Clinical Implications of Slope of GFR in Clinical Trials of CKD Progression
1. 请及时下载文件确认是否正确, 系统将在 2025-08-05 08:58:28 删除文件
2. 如若文件有误请驳回应助文件, 求助状态即回到求助中
3. 如若文件正确请及时点击确认, 若超过时后系统自动默认为已完结
注: 所有应助的资源仅供学习交流使用, 不得违反相关法律法规
DOI:
文献链接:
其他信息:
CKD-EPI Clinical Trials …
… Journal of the …, 2025
utsouthwestern.elsevierpure.com
BackgroundSlope of the GFR is considered a validated surrogate endpoint for CKD trials. However, differing short-term and long-term treatment effects on GFR slope can create ambiguities concerning the appropriate period for evaluating slope, in part because current methods cannot separate the distinct contributions of the acute (before 3 months) and chronic (after 3 months) slopes for treatment effects on clinical endpoints (CEs). MethodsWe estimated treatment effects on the acute and chronic GFR slopes and on the established CE …
