Silk fibroin/collagen hydrogel containing EDIL3 nanoparticles promotes pressure ulcer healing by promoting angiogenesis and remodeling local inflammation
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X Kan, L Luo, S Zhang, P Yao, J Chen, Y Jia…
Chemical Engineering …, 2025
Elsevier
The dressings for treating pressure ulcers (PUs) in clinical practice are inefficient and do not simultaneously improve angiogenic disorders and persistent inflammation. This study aimed to investigate the therapeutic effect of Silk fibroin/collagen hydrogel containing EGF-like repeats and discoidin I-like domains protein 3 (EDIL3) nanoparticles (NPs@ EDIL3-SF/Col hydrogel) on skin PUs and explore its potential mechanism of action to provide a theoretical basis for EDIL3 treatment of PUs. Through mass spectrometry, western blotting, and Gene …
