Imipramine and desipramine disposition in the elderly.
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DR Abernethy, DJ Greenblatt…
The Journal of …, 1985
jpet.aspetjournals.org
Forty-six healthy male and female volunteers aged 21 to 88 received single 12.5-mg iv doses of imipramine, and 35 of these people received single 50-mg po imipramine doses on a different occasion. Thirty-five similar volunteers received single 50-mg po desipramine doses. Among these subjects 25 participated in studies of both imipramine and desipramine. Kinetic variables for the respective drugs were determined from multiple plasma drug concentrations from samples obtained during 96 hr after the dosage. Imipramine half-life …
