Modeling relationship of pharmacokinetics, in vitro potency, and α4β7 receptor occupancy with intestinal cell trafficking in a gut-homing mouse model of IBD with MORF-057
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NS Redhu, A Hussain, S Srinivasan, D Lee…
The Journal of …, 2021
journals.aai.org
… We observed consistently high potency of MORF-057 across … to MORF-057. These data begin to establish the relationship between PK, target engagement, and PD with MORF-057. …